Susceptibility of bacterial endophthalmitis isolates to vancomycin, ceftazidime, and amikacin

Abstract Bacterial endophthalmitis is a rare intraocular infection, and prompt administration of intravitreal antibiotics crucial for preventing severe vision loss. The retrospective study to investigate the in vitro susceptibility vancomycin, amikacin, ceftazidime bacterial isolates specimens at tertiary referral center from January 1996 April 2019 Taiwan. Overall, 450 (49.9%) were Gram positive, 447 (49.6%) negative, 4 (0.4%) variable. In Gram-positive isolates, coagulase-negative staphylococci most commonly cultured bacteria (158, 35.1%), followed by Streptococci (100, 22.2%), Enterococci (75, 16.7%), Staphylococcus aureus (70, 15.6%). Gram-negative they Klebsiella pneumoniae (166, 37.1%) Pseudomonas aeruginosa (131, 29.3%). All organisms susceptible with exception one Enterococcus faecium isolate (1/450, 0.2%). Of 96.9% 93.7% respectively. Nine (9/447, 2.0%) multidrug-resistant bacteria, comprising K. (4/164, 2.4%), Acinetobacter baumannii (2/3, 67%), Stenotrophomonas maltophilia (3/18, 17%). conclusion, testing revealed that vancomycin remains suitable antibiotic treatment endophthalmitis. Ceftazidime amikacin provide approximately same degree coverage. Multidrug-resistant was uncommon.